Animal Models

Animal models of human disease have proved invaluable, in particular manipulation of the mouse genome using embryonic stem (ES) cells, transgene insertion, gene knockout and genome editing.

Pancreatic Intraepithelial Neoplasia (mouse)

We have a great depth of experience in gene modification via mouse ES cells but we are also at the cutting edge of the use of rat ES cells to create rat models of disease.

Genome editing technologies, including TALENs and CRISPRs, are used to modify the genomes of not only mice and rats but also pigs, sheep, chickens and zebrafish.

These provide new and powerful models for the understanding of pathology of human and veterinary disease.